Genetics

Weekly announcement: August 5-9

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Climate and Atopic Dermatitis: 5 Recent Studies to Consider

A growing body of research aims to understand how different climates affect AD.

The Role of Vitamins and Nutrients in the Management of Rosacea

A recent study reviewed the current evidence regarding the effect of essential vitamins and minerals on rosacea and provided clinical recommendations.

Topical vs Systemic Remedies: Rosacea Lesion Reduction Compared

A review of 43 studies found that systemic treatments often provide a greater reduction in rosacea ILs compared to topical treatments.

Journal Digest: August 5

This week’s roundup of the latest dermatologic studies includes oral dutasteride for frontal fibrosing alopecia, effects of air pollutants for patients with acne, bimekizumab in PsA patients without methotrexate, and itepecimab for humans adults with moderate to severe AD.

Hand Dermatitis Relief: Cotton Gloves vs Sympatex Liners

Participants experienced improvements with both types of gloves, although cotton gloves were generally preferred for comfort and Sympatex for sensitivity.

The Relationship Between Vitiligo and Psoriasis May Be Due, in Part, to Immunity

Skin with vitiligo and psoriasis shows an increased type of immune cells, with Mendelian analysis finding no causal relationship between the conditions.

Microneedling and CO2 Lasers Improve Acne Treatment

A recent study revealed that fractional laser was more effective than microneedling for the treatment of acne with ALA-PDT.

Success of CRISPR/Cas9 Technique Achieves 95% Exon Deletion for Treatment of Epidermolysis Bullosa

A new method using 2 single-directional RNA/Cas9 tools to target 3 specific parts of the COL7A1 gene with deleterious mutations was successfully removed in up to 95% of the parts those.

Questions and Answers: Alumis Inc. Initiates Phase 3 Clinical Program for ESK-001 in Plaque Psoriasis

Alumis’ Martin Babler shared details about the TYK2 inhibitor program and the company’s next steps for its development.

A Screening Questionnaire Developed for Type 2 Inflammatory Diseases

The 15-part questionnaire is designed to be quick and easy to use during interviews, and has specific benefits in many specialties.

JAK inhibition with Upadacitinib and Abrocitinib shows potential in the treatment of Rosacea

Recent research examined 6 patients with rosacea treated with JAK1 inhibitors upadacitinib and abrocitinib.

Vitiligo Symptoms Vary in Different Populations, According to Study

The findings highlight the need for interdisciplinary genetic studies to understand the broader impact on autoimmune diseases.

Experts Agree on the Role of AI in Aesthetics

An international panel of experts focused on the technology’s ability to guarantee and improve patient outcomes.

From OX40 Inhibition to Baby Pearls: Back to School Time for Doctors and Patients Alike.

Our August issue covers common back-to-school skin conditions, psoriasis research, OX40 prevention for atopic dermatitis, and baby skin conference highlights.

Study Reaches International Consensus for Methotrexate Dosing in Atopic Dermatitis Patients

The researchers say they hope this consensus guideline will inform decisions among nurses and encourage the development of a common practice.

Guselkumab Extended Dosing Proven Effective for Psoriasis

Both 8-week and 16-week dosing periods of guselkumab achieved similar clinical outcomes and patient-reported responses in the GUIDE trial.

Women of Color are Underrepresented in Vulvar Lichen Sclerosus Treatment Studies

Topical corticosteroids are the gold standard treatment for VLS, however women of color are underrepresented in studies.

Back to School, Back to the Show

Young patients are going back to school, and common skin problems like acne, eczema, warts and pigmentation can affect their confidence, Shanna Miranti, MPAS, PA-C, writes.

FDA Approves Denileukin Diftitox for Adults with Relapsed or Refractory Cutaneous T-Cell Lymphoma

Approval is supported by positive phase 3 data for Lymphir in this indication.

Piperacillin/Tazobactam shows potential in the treatment of severe HS

Recent results showed that 6 of 9 patients achieved HiSCR at 3 months, and 5 maintained this response at 6 months.

Vitiligo Care is Individualized: Part 1

Rocco Serrao, MD, FAAD, reviews the case of a 20-year-old man with segmental vitiligo and the psychological impact of his vitiligo.

Diamond-Augmented Zinc Oxide Technology Demonstrates Wound Healing, Collagen Synthesis, and More.

ND-ZnO technology has also been shown to penetrate the skin and deliver active ingredients.

Psoriasis Doesn’t Increase Risk of COPD, According to New Study

The prevalence of COPD in patients with psoriasis may be related to smoking, according to researchers.

Addressing the Challenges of Melasma Treatment and Achieving Trials in Melanin-Rich Skin

Melasma, which is challenging because of the different colors of different skin types, requires special, individualized care.

Study Identifying 3 Subtypes of Hidradenitis Suppurativa and Evaluating the Use of Secukinumab

Secukinumab improved outcomes in all groups, with more frequent dosing helping severe cases.

Comparing AI Models for Dermatological Diagnosis

The researchers stressed the need for the development of trust and regulatory rules for AI devices before they are implemented in dermatological practice.

Insights into NP/PA Perspectives on Emerging Treatment Options for Atopic Dermatitis

Check whether research providers are aware of current and emerging treatments for atopic dermatitis.

Study Confirms Link Between Environment and Psoriasis Risk

Researchers linked higher exposure to the natural environment and green spaces with an increased risk of developing psoriasis.

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